In the analysis of trans-acting CNAs, we identified several broadly affecting CNAs in genes that are potentially relevant to lung cancer, including PTK7, METTL1, MSTO1, PIGU, ITGA6, and LPCAT4. Following the exclusion of RNA and unannotated genes, we focused on investigating the effects of trans-acting ITGA6. We identified 262 upregulated and 142 downregulated genes based on their proteomic associations. This evidence concerns the gene ITGA6 and lung cancer.