CASP1 and alkaline phosphatase measurement: The natural compound wedelolactone has been reported to impede AP progression and associated lung injury through the canonical caspase-1-mediated pyroptotic pathway and caspase-11-mediated non-canonical pyroptotic pathway.475 Li et al. demonstrated that hair follicle-derived mesenchymal stem cell-derived small extracellular vesicles alleviated AP by suppressing inflammation and pyroptosis in pancreatic acinar cells.