The Bushen Huoxue acupuncture technique diminishes Aβ generation in the hippocampal tissue of SAMP8 mice, suppresses NLRP1 inflammasome activation-medicated pyroptosis, and ultimately enhances cognitive function in mice with AD.387 Specific blockades of caspase-GSDM-mediated pyroptosis have demonstrated noteworthy neuroprotective effects in animal models of AD. Here, GSDMA is linked to Alzheimer disease.