NLRP3 and hepatocellular carcinoma: Subsequently, this activation led to the cleavage of gasdermin D into its N- and C-terminal domains, facilitating the induction of pyroptosis.333 The therapeutic potential of alpine pine flavones (AIF) against HCC has been investigated and demonstrated suppression of proliferation, migration, and invasion in Huh7 and SMMC7721 cell lines, possibly through the excitement of NLRP3 inflammasome assembly, which has also been verified by in vivo findings.334 Metformin, recognized for its glucose-lowering effects, also exhibits antineoplastic effects in HCC by triggering apoptosis and pyroptosis.