NLRP3 and acute kidney injury: USF2 upregulated THBS1 to activate the TGF-β/NLRP3 signaling pathway, provoking pyroptosis and further aggravating sepsis-induced AKI.235 According to a recent study, dsDNA-induced AIM2 pyroptosis rapidly removes macrophages, which unexpectedly halts aberrant inflammation during AKI triggered by rhabdomyolysis.236 Baatarjav et al. revealed the pivotal role of GSDME-mediated pyroptosis in AKI development.