GSDMD and diabetic kidney disease: Loganin mitigates pyroptosis in HK-2 cells triggered by high glucose levels by suppressing ROS generation and NLRP3 inflammasome activation, resolving renal pathologies in DKD mice, similar to ManNAc in podocytes.436,437 Likewise, the anti-pyroptotic effect of the Tangshen formula acts via the TXNIP-NLRP3-GSDMD axis.438