GSDMD and cancer: HCC is one of the primary causes of cancer-related death, and its prevalence is anticipated to increase globally.148 A recent study found that soluble resistance-related calcium-binding protein (sorcin) impairs the assembly of the NLRP3 inflammasome, thus inhibiting cell pyroptosis and provoking HCC progression.130 A noteworthy association was found in HCC cells between the expression of GSDMD and NEK7.