HMOX1 and ischemic stroke: METTL14 (methyltransferase-like 14) was found to activate the NLRP3 inflammasome/pyroptosis axis via KAT3B-STING signaling after oxygen-glucose deprivation/reperfusion (OGD/R), which simulates ischemic stroke in vitro.177 Wei et al. demonstrated that TRIM27 downregulated NLRP3 inflammasome-mediated pyroptosis through Akt/Nrf2/HO-1 signaling, ameliorating ischemic stroke.178 Likewise, TRIM29 (Tripartite Motif Containing 29) was reported to exert a negative regulatory effect on pyroptosis in ischemic stroke.179