CASP8 and neoplasm: Furthermore, other caspases, such as caspase-8 and caspase-9, have been explored for their interactions with pyroptosis in tumor cells, illustrating a diverse range of potential therapeutic approaches.349,371–373 Moreover, a mechanism of sorafenib therapy against HCC tumors through inducing macrophage (MΦ) pyroptosis and triggering an NK-cell response was explored.