For instance, halotherapy was found to alleviate oxidative stress in the lung tissues of COPD rats, diminish the accumulation of CD4+ and CD8+ T cells in the lungs, and reduce the production of inflammatory factors in the serum by suppressing the TLR4/NF-κB/GSDMD and NLRP3/ASC/caspase-1 pathways.418 The success of halotherapy in alleviating pyroptosis in patients with COPD provides incentives for the more detailed exploration of physical treatments in respiratory diseases. Here, CD8A is linked to chronic obstructive pulmonary disease.