Lu et al. discovered that the protective role of irisin and mitochondrial ubiquitin ligase (MITOL/MARCH 5) in DCM was partially offset by the activation of cGAS/STING signaling, inhibiting GSDMD-mediated pyroptosis.463 Targeting Nrf2 has a pivotal role in inhibiting pyroptosis. Here, GSDMD is linked to familial dilated cardiomyopathy.