Subsequently, the canonical caspase-1-GSDMD pyroptosis pathway is induced, contributing to tubular injury and interstitial inflammation.231 NETs have also been reported to induce glomerular endothelial cell (GEC) pyroptosis, mediated by charge, further inducing the development of DKD.247 Over the past few years, other molecules and substances, such as circRNA, LncRNA, and lysophosphatidic acid have also been reported to target the regulation of pyroptosis in DKD.248–252. This evidence concerns the gene CASP1 and diabetic kidney disease.