GSDMD and neoplasm: This finding suggests that inhibiting NLRP3 acetylation or inflammasome assembly could be a viable strategy for halting the advancement of PCa.337 Yan et al. demonstrated that cisplatin induces the NLRP3/caspase-1/GSDMD pyroptosis pathway through the elevation of long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) in TNBC, contributing to its anti-tumor activity.