CASP3 and neoplasm: Curcumin, the principal active compound in turmeric, triggers caspase-1/GSDMD-dependent pyroptosis in leukemia cells by boosting the expression of the IFI16, AIM2, and NLRC4 inflammasomes through the stimulation of ISG3 transcription factor activity.348 Li et al. showed that dihydroartemisinin (DHA) activates the AIM2/caspase-3/GSDME axis, initiating pyroptosis in breast cancer cells.349 Moreover, elevated CCL19 expression markedly suppresses the proliferation of gastric cancer cells and tumor progression, both in vitro and in vivo, by enhancing the CCR7/AIM2 pathway.