During DKD, caspase-11/4 and GSDMD-mediated pyroptosis are activated, contributing to podocyte loss.246 A recent study demonstrated that alpha‐kinase1 (ALPK1) was activated by hyperglycemia and caused phosphorylation of NF-κB in renal tubular epithelial cells in DKD. The gene discussed is ALPK1; the disease is diabetic kidney disease.