CASP1 and colonic neoplasm: Recent studies have revealed its ability to generate intracellular ROS in colon cancer cells, subsequently activating caspase-1 and initiating caspase-1-dependent pyroptosis.366 However, the ROS-generating effect of simvastatin was evaluated in 2016, with the results showing nonsignificant differences with the placebo group.367 Therefore, further evidence is required for the treatment outcome of colon cancer in vivo.