Coenzyme Q0 suppresses HIF-1α expression and inhibits the NLRP3 inflammasome, as well as ASC/caspase-1 expression, resulting in the downregulation of IL-1β and IL-18 expression in MDA-MB-231 and 468 cells and inhibition of EMT/metastasis of human TNBC and HNSCC cells.342,343 This opposite result implies that in different cancers and different periods of tumor progression, pyroptosis may play different roles, and the treatment strategy should vary accordingly. This evidence concerns the gene CASP1 and cancer.