Epigallocatechin-3-gallate, a bioactive polyphenol isolated from green tea, protects cardiomyocytes from pyroptosis via the MEG3/TAF15/AIM2 axis, thereby inhibiting AIM2 expression.455 Moreover, other targets in the canonical pathway, such as GSDMD, have gained attention in MI. This evidence concerns the gene AIM2 and myocardial infarction.