TLR4 and myocardial infarction: For example, geniposide promotes AMPK phosphorylation, Tanshinone IIA and Qighen granule suppress the TLR4/NF-κB p65 signaling pathway, hydrogen gas inhalation reduces the production of ROS, and chlorogenic acid depresses lncRNA Neat1 expression, ultimately impacting cardiomyocyte pyroptosis.449–453 In clinical trials, coenzyme Q10 is verified to suppress the recruitment of pro-inflammatory CCR2+ macrophages by attenuating the activation of the NLRP3/ IL-1β pathway, ameliorating MI.454 The AIM2 inflammasome also exhibits therapeutic potential in MI.