Mechanistically, STING/NF-κB/p65 pathway downregulation attenuated NLRP3-mediated pyroptosis.243 GSDME was found to contribute to renal tubulointerstitial fibrosis and renal dysfunction induced by ureteral obstruction and 5/6 nephrectomy via pyroptotic cell death.244 In addition, a new study illustrated the collaboration of GSDMD and GSDME in the transition of AKI to CKD.242. This evidence concerns the gene NLRP3 and acute kidney injury.