NLRP3 and alkaline phosphatase measurement: Furthermore, compared to the effect of small extracellular vesicles administered intraperitoneally, the therapeutic effect of small extracellular vesicles following intravenous injection seems to be enhanced.476 Qingjie Huagong decoction, a formula consisting of seven traditional medicines, has been reported to exert its anti-AP effects by regulating the circHipk3/miR-193a-5p/ NLRP3 pathway.477 Other therapeutic strategies have also emerged to target pyroptosis in the pathology of AP, including baicalein, disulfiram, sinapic acid, and salidrosidet.478–481