In an ovalbumin-induced asthmatic mouse model, GSDMD silencing significantly reduced Th17 and Th2 inflammatory responses as well as M2 macrophage polarization, all of which are involved in airway remodeling and inflammation.214 Dectin-1 activation in asthma provoked caspase-11/4-mediated macrophage pyroptosis, thereby stimulating the secretion of chemokines and aggravating airway neutrophil inflammation.215 MUC1 suppressed NLRP3 inflammasome-mediated pyroptosis via blocking the TLR4/ MyD88/NF-κB pathway, subsequently alleviating neutrophil airway inflammation in asthma.216. This evidence concerns the gene TLR4 and asthma.