NFKB1 and diabetic kidney disease: During DKD, caspase-11/4 and GSDMD-mediated pyroptosis are activated, contributing to podocyte loss.246 A recent study demonstrated that alpha‐kinase1 (ALPK1) was activated by hyperglycemia and caused phosphorylation of NF-κB in renal tubular epithelial cells in DKD.