In a study of an LPS-induced peritonitis model and an MSU-induced gout model33, Deng et al. reported that DSF prevented the release of lysosomal protease B from lysosomes into the cytoplasm and directly inactivated the NLRP3 inflammasome, thereby inhibiting the activation of downstream pyroptosis pathways23. This evidence concerns the gene NLRP3 and peritonitis.