Through co-culturing neutrophils from peripheral blood samples from human subjects and co-culturing them with SW480 colon cancer cells and inducing NETs, treatment with varying concentrations of EGCG led to suppressed NET formation, decreased expression of STAT3 and CXCL8 in colon cancer cell-derived neutrophils, and impaired cancer cell migration and invasion.88 This evidence concerns the gene STAT3 and malignant colon neoplasm.