GSDMD and acute pancreatitis: Disulfiram, for example, has been found to reduce NET expression through gasdermin D inhibition, and alleviated severe inflammatory injury in acute pancreatitis.624 Ling et al. demonstrated in a murine model of severe acute pancreatitis induced by caerulein and LPS that treatment with either 50 mg/kg or 100 mg/kg of disulfiram led to inhibition of gasdermin D and resultant decrease in in-vivo NET formation, in turn alleviating inflammatory injury.624