Specifically, 1) cancer-induced platelet activation and NET release contribute to the hypercoagulable state in cancer;600,601 2) tumor-derived pro-coagulant micro particles promote DVT by carrying tissue factor and adhering to thrombus-associated NETs;602 3) NETs released from cancer patients increase levels of thrombin-ant thrombin complexes and enhance the ability of control plasma to generate fibrin.41 Administration of DNase I reduced thrombus size in mice bearing human tumors.512,603. This evidence concerns the gene DNASE1 and cancer.