Only CXCR1/2/4 have been identified to be implicated in NET formation to date.200 For example, CXCR1 and CXCR2 have been confirmed to be involved in mediating chemokines-promoted NETosis in tumors.201 CXCR2 induces NET formation by cooperating with PSGL-1, which signals the recruitment of neutrophils, thereby further promoting deep vein thrombosis.202 Overlapping subsets of immune cells express sialic acid-binding immunoglobulin-like lectins (Siglecs). Here, CXCR2 is linked to deep vein thrombosis.