CXCR1 and neoplasm: Evidence has also shown that CXCR1 and CXCR2 agonists produced by tumor cells promote NET formation, which act as a protective shield against cytotoxicity mediated by NK cells and T cells.201,565 Additionally, studies have validated that NETs protect tumor cells by creating a physical barrier at the tumor/stroma interface,566,567 thus preventing the infiltration of CD8+ T cells into tumor cell areas.