MYH9 mutation leads to MYH9-related disease (MYH9-RD), which is a blood disease clinically manifested by thrombocytopenia with giant platelets.34 In cancers, the role of MYH9 as a tumor suppressor gene or an oncogene is controversial.35 MYH9 participates in cancer development by performing various functions, such as a transcriptional factor and a deubiquitinase.26 Thus, the mechanisms by which MYH9 is involved in HCC stemness and LR are meaningful and interesting. This evidence concerns the gene ENSG00000280371 and hepatocellular carcinoma.