Recent studies have focused on the role of MYH9 phosphorylation in cancer progression.36,37 It has been identified that phosphorylation of MYH9 by protein kinase C (PKC) on Ser1916 and CK2 on Ser1943 is related to poor prognosis and could be a therapeutic target.26 In this study, HIF-1α was found to be upregulated in HCC LR cells and promoted cancer stemness and glycolysis even in normoxia. This evidence concerns the gene PRRT2 and hepatocellular carcinoma.