HIF1A and neoplasm: By targeting these specific markers, it may be possible to selectively eliminate CSCs and prevent tumor recurrence and metastasis.12 Hypoxia-inducible factor-1α (HIF-1α) and HIF-1β form the oxygen-sensitive transcription factor HIF-1, a major transcription factor that promotes the progression of a variety of tumors.13,14 HIF-1α participates in the development of CSCs by regulating the transcription of target genes.15 Under hypoxia, reduced oxygen leads to stabilization of HIF-1α.