Some of the transcription factors whose networks are strongly perturbed in both AUD and advanced AD are depicted in Figure 11: EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit), SON, SOX5, BCL11B, NFIB, ATRX, and TET1; the entire network of these transcription factors can be found in Extended Data Table 11-1. Here, ATRX is linked to Alzheimer disease.