Other pathways indicative of neurodegeneration (gene sets, Pathways of neurodegeneration, Parkinson disease, Huntington disease, Amyotrophic lateral sclerosis, Alzheimer's disease) were also downregulated in L5 ET, L5 IT, L6 CT, L4 IT, L6b, L6 ITCar3, Chandelier, Sst, Vip, and Lamp5Lhx6 neurons. The gene discussed is VIP; the disease is Alzheimer disease.