One such gene is STC1 that in a study on humans was shown to have been overexpressed in the cerebrospinal fluid of patients with other dementias and ultimately had inconclusive results for AD dementia (Shahim et al., 2016), and on the contrary, in a study in mice, its overexpression was found to improve cognition and neuroinflammation (P. Wang et al., 2021). Here, STC1 is linked to dementia.