Tubulin binding has been found to be significantly lower in AD patients due to deposition of hyperphosphorylated tau proteins that have low tubulin affinity which causes microtubule destabilization, ultimately leading to compromised axonal and synaptic integrity (Zhang et al., 2015; Fernandez-Valenzuela et al., 2020; Santiago-Mujika et al., 2021). Here, MAPT is linked to Alzheimer disease.