TET1 (ten–eleven translocation methylcytosine dioxygenase 1) has NPAS3 (neuronal Per-Arnt-Sim 3) as a target (Extended Data Table 6-2) that is associated with schizophrenia (Kamnasaran et al., 2003) essential for synaptic plasticity in turn affecting learning and retention. This evidence concerns the gene TET1 and schizophrenia.