We found ADAMTS18 (a disintegrin and metalloproteinase with thrombospondin motifs) to be significantly downregulated in oligodendrocytes, while Ramamurthy et al. (2023) found significant increase in its transcription in the dorsolateral prefrontal cortex in AD; CABCOO1 (ciliary-associated calcium-binding coiled–coil protein) is significantly upregulated in VLMCs, supported by Extended Data Figure 6-1, which indicates dysregulation of calcium signaling pathway. Here, ADAMTS18 is linked to Alzheimer disease.