NOX4 and Alzheimer disease: NOX4 (NADPH oxidase 4) has been shown by Park et al. (2021) to promote ferroptosis in non-neuronal cells via oxidative stress-induced lipid peroxidation by dysregulation of metabolism of mitochondria; we found it to be upregulated in all AD stages, but its log-fold change is maximum in endothelial cells of early AD; the respective endothelial cells’ log-fold change in early through advanced AD is 2.41, 2.23, and 1.75, respectively.