PDGFRB and Alzheimer disease: PDGFRB is upregulated after brain injury, and its depletion results in blood–brain barrier damage; Sun et al. (2023a) highlighted PDGFRB, platelet-derived growth factor-BB, as a significant marker for pericyte cells in AD-related vascular changes (Sun et al., 2023a), consistent with our finding of its exclusive downregulation in endothelial cells of intermediate AD.