We found synaptic signaling and neuron projection pathways like anterograde transsynaptic signaling, chemical synaptic transmission, postsynaptic density, neuron projection guidance, neuron projection, and asymmetric synapse to be significantly negatively enriched in the inhibitory cell types and L6 IT Car3 excitatory cells in all AD stages, which is consistent with the findings of Mathys et al. (2023). The gene discussed is CA3; the disease is Alzheimer disease.