EDA2R and Alzheimer disease: One such example is TNF (tumor necrosis factor) family receptor EDA2R (ectodysplasin A2 receptor) that is proinflammatory and has been found to be associated with proinflammation of tau protein (Duan et al., 2021) and was also found to be the strongest protein biomarker of cognitive ability in the plasma of a cohort of aged individuals (Harris et al., 2020); we found it to be significantly upregulated in endothelial cells of early AD samples.