It is upregulated in most glutamatergic cells and is involved in adenylate cyclase-activating G-protein–coupled receptor (GPCR) signaling pathway in early AD, as can be seen in Extended Data Figure 6-1, and GPCR kinases have been implicated to be associated with AD (Guimarães et al., 2021). This evidence concerns the gene ADCY1 and Alzheimer disease.