We found SPOCK2 as a target of ATRX and SPOCK3 as a target of TET1 (Extended Data Table 6-2, a paralog of which, SPOCK1, was recently found to make region-specific blood–brain barrier permeable in neurodegenerative diseases in zebrafish and mice, making the brain more susceptible to infections (O’Brown et al., 2023). This evidence concerns the gene SPOCK3 and neurodegenerative disease.