Another interesting find, TCIM (transcriptional and immune response regulator), that is significantly upregulated in early and intermediate AD (respective log-fold change, 2.01 and 1.22) in vascular endothelial cells has been found to mediate inflammatory responses in endothelial cells via NF-kB signaling (T. Liu et al., 2017; J. Kim et al., 2009); we also found it significantly downregulated in VLMC in advanced AD (log-fold change, −1.03). The gene discussed is TCIM; the disease is Alzheimer disease.