HCRTR2 and Alzheimer disease: Dysregulation of genes, in both AD and AUD, included QRFPR GPCR103, the neuropeptide QRFP receptor, and HCRTR2, one of the two hypocretin/orexin receptors that regulate sleep, which is disrupted in AD patients (Fronczek et al., 2012; Scammell et al., 2012; J. Davies et al., 2015; Z. Ma et al., 2016).