Inflammation-related genes are among the significant markers like the proinflammatory cytokine IL6 (interleukin 6) that is associated with brain atrophy in AD (Capogna et al., 2023), IL2RB that is a part of the IL-2 receptor complex, CD247 that is known to cause immune reactions in the peripheral blood lymphocytes in AD patients (Ikeda et al., 1991; Xu and Jia, 2021), and IL1RL1 that encodes for soluble ST2 (sST2), a decoy receptor of interleukin-33–ST2 signaling, which has been identified as a genetic risk factor for AD (Jiang et al., 2022). Here, IL6 is linked to Brain atrophy.