TCIM and Alzheimer disease: For example, we found autophagy-related genes and pathways perturbed in early AD, which is consistent with previous findings (Uddin et al., 2018; Mathys et al., 2023), and a number of genes in vascular cell types that dysregulate transcription and are proinflammatory, like TCIM and EDA2R, suggesting these core AD marker pathologies begin in brain vasculature (Duan et al., 2021; J. Kim et al., 2009; T. Liu et al., 2017; Sun et al., 2023a).