We found SPOCK2 as a target of ATRX and SPOCK3 as a target of TET1 (Extended Data Table 6-2, a paralog of which, SPOCK1, was recently found to make region-specific blood–brain barrier permeable in neurodegenerative diseases in zebrafish and mice, making the brain more susceptible to infections (O’Brown et al., 2023). The gene discussed is SPOCK3; the disease is infection.