We found Rab genes (known to regulate autophagy by the Rab GTPase network; Ao et al., 2014), RAB37 and RAB38, are significantly upregulated in early AD (log-fold change of 2.02 in Sst Chodl cells and 2.03 in endothelial cells, respectively); autophagy-related genes were also observed in Mathys et al. (2023) to be associated more with early AD changes relative to late AD. This evidence concerns the gene RAB6A and Alzheimer disease.