Recurrence of ICI hepatitis was present in 22% of all rechallenged cases, mainly in anti–PD-1/PD-L1 agents, and was noted to be not as severe as the initial event.34,45,48 Hountondji et al48 suggested that rechallenge was even possible after grade 3-4 hepatitis. This evidence concerns the gene PDCD1 and hepatitis A virus infection.