This is in agreement with a recent study using single cell RNA-seq to map the differentiation trajectories of CD34+ progenitors in CMML primary patient samples [59] where the authors also showed the upregulation of CD116 in a cell cluster enriched for granulocyte/monocyte progenitor-like inflammatory hematopoietic stem and progenitor cells that may have self-renewal capacity in CMML patients with a monocyte-biased differentiation trajectory. This evidence concerns the gene CD34 and chronic myelomonocytic leukemia.