To explore whether tumor intrinsic mPGES-1 is associated with an immunosuppressive tumor microenvironment (TME) in PDAC, we analyzed the expression of Ptges, the gene encoding the mPGES-1 enzyme, in clonal tumor cell lines generated from tumors that arose spontaneously in C57BL/6J congenic KrasG12DP53R172HCrePdxYfp (KPCY) and KPC mice. Here, PTGES is linked to neoplasm.