RNA-seq analysis of YFP+ tumor cells sorted from s.c. implanted tumors revealed a decrease in transcript counts for genes encoding 3 adenosine-synthesizing enzymes, CD73, CD38, and CD203a, and an increase in CD39 transcript counts, in Ptges-KO and Ptger4-KO tumors (Supplemental Figure 9D). This evidence concerns the gene PTGES and neoplasm.