Furthermore, a study detected 363 differentially accumulated proteins in patients with EoE compared to healthy subjects, including eosinophil-associated proteins (e.g., RNASE2, RNASE3, SERPINC1, EPX, and PRG3) that correlated with eosinophil counts and disease severity, proposing new, minimally invasive biomarkers [101]. The gene discussed is PRG3; the disease is eosinophilic esophagitis.