This study highlighted a significant enrichment of CD4 + regulatory T cells (FOXP3 +) and Th2 cells (GATA3 +) within tissue-residing CD3 + T cells, localizing type 2 cytokine production to these effector populations and suggesting a role for FFAR3 in amplifying local Th2 responses in EoE. The gene discussed is CD4; the disease is eosinophilic esophagitis.