Additionally, liquid chromatography-tandem mass spectrometry (LC–MS/MS) comparisons of esophageal biopsies from pediatric EoE, gastroesophageal reflux disease (GERD), and healthy controls identified eosinophil cationic protein (ECP) as significantly upregulated in EoE [100]. Here, RNASE3 is linked to gastroesophageal reflux disease.