Another meta-analysis, including 1,930 affected European subjects and 13,634 ancestry-matched controls, identified 15 genome-wide significant EoE risk loci, 11 of which were novel; three loci, 5q31.1 (RAD50), 15q22.2 (RORA), and 15q23 (SMAD3), may have a pivotal role in EoE development [23]. Here, SMAD3 is linked to eosinophilic esophagitis.