CD30 expression is upregulated in several IMIDs, including RA, SLE, AD, and asthma (Oflazoglu et al., 2009), and CD30 polymorphisms are associated with eczema (Table 2), suggesting that CD30/CD30L signaling could be an important determinant of inflammatory processes in these diseases. The gene discussed is TNFRSF8; the disease is systemic lupus erythematosus.