The elevated levels of serum BAFF in SLE patients are associated with increased anti-dsDNA levels (Zhang et al., 2001) and SLE disease activity (Petri et al., 2008), and may be driven by TNFSF13B variants associated with SLE risks (Steri et al., 2017; Theodorou et al., 2018). This evidence concerns the gene TNFSF13B and systemic lupus erythematosus.