Thirteen peptides from salmonco-products (frames) were identified,chemically synthesized, and tested for their antidiabetic bioactivities.IPVE increased glucose uptake by muscle cells (L6 myocytes), IVDIand IEGTL decreased hepatic glucose production (HGP) of insulin, whereasVAPEEHPTL decreased HGP under both basal conditions and in the presenceof insulin in FaO cells from rat hepatoma.108 The peptides identified in this investigation primarily consistof hydrophobic AAs such as Ala, Gly, Ile, Leu, Pro, and Val. Here, INS is linked to hepatocellular carcinoma.