A study collected human hepatoma cells Hep3B and Huh7 and revealed that DNMT1 can be recruited to the SPRY2 promoter and first intron to promote SPRY2 promoter methylation, thereby silencing SPRY2expression,16 while the mechanism of SPRY2 and DNMT1 proteins in melanoma has not been clearly reported. This evidence concerns the gene DNMT1 and melanoma.