A study collected human hepatoma cells Hep3B and Huh7 and revealed that DNMT1 can be recruited to the SPRY2 promoter and first intron to promote SPRY2 promoter methylation, thereby silencing SPRY2expression,16 while the mechanism of SPRY2 and DNMT1 proteins in melanoma has not been clearly reported. The gene discussed is SPRY2; the disease is melanoma.