Loss of rod photoreceptors is followed by loss of cone photoreceptors, causing an irreversible decline in visual acuity that may lead to blindness.[2, 3] The Pde6a gene encodes the α subunit of rod‐specific cyclic guanosine monophosphate (cGMP)‐phosphodiesterase, a critical enzyme involved in the phototransduction cascade within rod photoreceptor cells.[2] Mutations in PDE6A disrupt the function of this enzyme, leading to dysregulation of cGMP levels and subsequent photoreceptor cell death. This evidence concerns the gene PDE6A and blindness (disorder).