Studies by Cui et al. and Sun et al. linked high GSDMC expression to poor survival in kidney renal clear cell carcinoma and breast invasive carcinoma, respectively.[26, 27] In lung adenocarcinoma, elevated GSDMC expression was also associated with a negative outcome.[28] A recent systems analysis for pancreatic cancer suggested GSDMC's potential role in regulating PDAC cell proliferation.[29] These findings consistently indicate that GSDMC overexpression is linked to poor outcomes in various cancer types, but the functional implications and underlying mechanisms remained elusive. The gene discussed is GSDMC; the disease is lung adenocarcinoma.