To conclusively validate the hypothesis that GSDMC promotes in vivo progression of PDAC by modulating the immunosuppressive tumor microenvironment, we utilized a murine PDAC model based on PDAC cells derived from KPC mice (LSL‐KrasG12D/+; LSL‐Trp53R172H/+; Pdx‐1‐Cre) combined with genetic targeting of murine Gsdmc (shGsdmc) versus no targeting (shNC). The gene discussed is PDX1; the disease is neoplasm.