TGFBR2 and adenocarcinoma: Miguchi et al. reported that the depletion of Apc and Tgfbr2 led to adenocarcinoma formation in the colon, accompanied by a significant increase in Gsdmc expression.[25] Silencing Gsdmc led to decreased proliferation and tumorigenesis of colorectal cancer cell lines, while its overexpression enhanced their proliferation.