GSDMC and cancer: Importantly, as our previous studies have shown, cancer stem cells are essential for tumor initiation and metastasis, but once solid tumors have established, cancer stem cells appear to become mostly dispensable for primary tumor growth that is driven by the expansion of their highly proliferative progenies.[8, 10, 42] Therefore, GSDMC inhibition alone primarily prevents tumor initiation and metastasis, when immune surveillance is also particularly relevant, leading to increased median survival.