Key regulators such as CUG‐binding protein 1 activate phosphodiesterase 3B (PDE3B), influencing insulin secretion,[12] whereas DEAD box 1 (DDX1)‐mediated inhibition of insulin translation exacerbates insulin resistance in individuals with obesity, leading to elevated blood glucose levels.[13] These findings underscore the essential role of RBPs in maintaining the functionality of mouse β cells. The gene discussed is PDE3B; the disease is obesity due to melanocortin 4 receptor deficiency.