STAT3 and renal cell carcinoma: The lncARSR could also interact with miR-34/miR-449 to upregulate the expression of signal transducer and activator of transcription 3 (STAT3) to induce the polarization of M2 macrophages in RCC, which may lead to tumor progression and metastasis due to immunosuppression function of M2 macrophages (37).