Besides, the upregulation of HIF-1α in macrophages could increase the expression of miR-193a-5p, and later the exosomes produced by tumor-associated macrophages (TAMs) could traffic the miR-193a-5p towards the 3’ untranslated region (UTR) of TIMP2 mRNA in the RCC cells. Here, TIMP2 is linked to neoplasm.