The lncARSR could also interact with miR-34/miR-449 to upregulate the expression of signal transducer and activator of transcription 3 (STAT3) to induce the polarization of M2 macrophages in RCC, which may lead to tumor progression and metastasis due to immunosuppression function of M2 macrophages (37). This evidence concerns the gene LNCARSR and renal cell carcinoma.