Therefore, WFDC12 likely facilitates the infiltration of LCs into the epidermis and lymph nodes, and this elevated production of IL-12 then helps in promoting the differentiation of lymph nodes and peripheral blood Th1 cells, resulting in the secretion of IFN-γ in the damaged region of the IMQ-induced psoriasis mice. This evidence concerns the gene WFDC12 and psoriasis.