In psoriasis, WFDC12 affects the activation of the retinoic acid signaling pathway and regulates the infiltration of DC cells in the skin lesions and lymph nodes, inducing Th1 cell differentiation and increasing the secretion of IFN-γIn AD, the overexpressed-WFDC12 may affect the development of AD by promoting ALOX12/15 metabolism and PAF accumulation. This evidence concerns the gene WFDC12 and Alzheimer disease.