The present study examined the effects of propolis on liver enzymes and obesity-related indices, and a total of 24 studies were included, on the basis of which propolis was able to decrease ALT and AST significantly, but its effects on GGT and ALP and obesity-related indices including weight, BMI, fat mass, body fat percentage, fat-free mass, WC, hip circumference, WHR, adiponectin were not statistically significant. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.