VEGFA and age-related macular degeneration: EPA application substantially reduced the expression of intercellular adhesion molecule 1 (ICAM-1) and monocyte chemotactic protein 1 (MCP-1) in endothelial cells and the expression of VEGF and interleukin-6 (IL-6) in macrophages, effects which have anti-inflammatory and anti-angiogenic properties (29), and it is known that inflammatory effects play an important role in the occurrence and development of AMD (27).