IL17A and psoriasis: In addition, L-amino acid transporter 1 (LAT1) expression levels were significantly increased in T cells from lesional skin lesions of psoriasis patients and IMQ-induced mouse models, and LAT1 promoted the proliferation of IL-17+ γδ T cells and Th17 cells and the secretion of IL-17 and IL-22 through the PI3K/Akt/mTOR pathway, while the LAT1 inhibitor JPH203 significantly improved IMQ-induced psoriasiform lesions in mice (102).