IL22 and psoriasis: In addition to inhibiting the proliferation of keratinocytes (HaCaT and NHEKs cells) and inducing their apoptosis, Min et al. demonstrated that rottlerin significantly obstructs the secretion of psoriasis-promoting cytokines (TNF-, IL-6, IL-17, IL-22, and IL-23) at concentrations of 0 μM, 1 μM, 5 μM, and 10 μM (45).