In addition, in infection-derived uveitis the p38MAPK pathway is activated in Müller glia, which has been associated to the expression of pro-inflammatory factors (e.g., IL-6, ICAM-1, CXCL1, CXCL10, CCL2 and CCL5 and CCL7), ECM deposition (mainly fibronectin and collagen IV) and tissue stiffening (137, 181). This evidence concerns the gene FN1 and uveitis.