TS pathophysiology has been linked to a disturbed migration of cholinergic interneurons into the striatum (Kataoka et al. 2010), disturbed dopaminergic transmission (Maia and Conceição 2018), and, in rare monogenetic forms, a loss-of-function in the SLITRK1 gene (Abelson et al. 2005). The gene discussed is SLITRK1; the disease is Timothy syndrome.