The majority are considered the key regulators of epithelial differentiation and organ development, i.e., CP2 [84], the maintenance of the germline stem cells, i.e., USF [85], enhancers that activate transcriptional programs and cellular reprogramming, i.e., GATA1 and GATA 3 [86], favor cell growth and proliferation, i.e., AP1 and AP4 [87], and facilitate TJ formation in carcinoma cells, i.e., HNF4 [88]. The gene discussed is HNF4A; the disease is carcinoma.