FGF21 and diabetes mellitus: Studies have shown that FGF-21 can reduce cell death induced by oxidative stress and autophagy, which is beneficial to remyelination and nerve regeneration after peripheral nerve injury and plays an important role in diabetes (29).Cheng’s study showed that type II diabetes had a protective effect on osteoporosis, and for each additional case of type II diabetes, the incidence of osteoporosis decreased by 0.15% (30).