METTL3 and Hyperglycemia: Meanwhile, in Pdx1+ pancreatic progenitor cells, absence of METTL3 could inhibit Hdac1 expression and further activate wnt/β-catenin and Notch/Hes1 pathways, leading to hyperglycemia and hypoinsulinemia, along with an atrophic pancreas, reduced islet mass, and abnormal increase in ductal formation (81).