Similarly, different biochemical phenotypes have been described in canine obesity; for example, adiponectin concentration was less and plasma insulin concentration greater in dogs with obesity that met the criteria of ORMD, which was defined as having obesity plus two other criteria amongst: TG >200 mg/dL (>2.26 mmol/L), total cholesterol >300 mg/dL (>7.8 mmol/L), systolic blood pressure > 160 mmHg, and either a fasting plasma glucose >100 mg/dL (>5.6 mmol/L) or previously diagnosed diabetes mellitus (15, 16). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.