No statistically significant differences in genotype frequencies were detected among the investigated groups (COVID-19 patients with MAFLD, COVID-19 patients without MAFLD, and controls) for the four polymorphisms analysed: IFNAR2 rs2236757 (χ2 = 0.496, df = 4, p = 0.974), ACE2 rs2074192 (χ2 = 1.310, df = 4, p = 0.8597), OAS1 rs10774671 (χ2 = 2.432, df = 4, p = 0.6569), and OAS3 rs10735079 (χ2 = 2.314, df = 4, p = 0.6783) (Figure 1). This evidence concerns the gene OAS3 and COVID-19.