The ARID1A variants identified, including the c.3189_3190delinsC (p.Leu1064fs) and c.5320G>T (p.Glu1774*) mutations, highlight the ongoing relevance of chromatin remodeling genes in endometrial cancer, a finding that has been previously reported but remains an area of active research. The gene discussed is ARID1A; the disease is endometrial cancer.