Several key pathogenic variants were identified in somatic samples, including mutations in well-known cancer-associated genes such as PIK3CA, KRAS, PTEN, and TP53. These mutations are critical drivers of oncogenesis, influencing pathways like PI3K/AKT and MAPK/ERK, which are integral to cell proliferation, survival, and tumor growth. This evidence concerns the gene KRAS and neoplasm.