After 1989, it became universally acknowledged that the underlying cause of CF is represented by genetic mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene located on chromosome 7q31.2 [3], which encodes the CFTR protein responsible for the epithelial chloride ion channel, a focal point of modulation for several important functions [4]. This evidence concerns the gene CFTR and cystic fibrosis.