eNOS has a central role in endothelial homeostasis and is generally viewed as serving a beneficial role in lung inflammation (Qi et al., 2016; Guimarães et al., 2021; Ren et al., 2021) and ARDS (Albertine et al., 1999; Vassiliou et al., 2021). The gene discussed is NOS3; the disease is acute respiratory distress syndrome.