Asthma is marked by airway hyperresponsiveness (AHR), increased infiltration of eosinophil and other inflammatory cells into the lungs, activation of T-helper two cells, higher levels of inflammatory cytokines (such as interleukin (IL)-4, IL-5, IL-13, IL-17, IL-1β, and IL-33), and noticeable histopathological changes (such as mucus hypersecretion, airway smooth muscle hypertrophy, and airway narrowing) (Aslani et al., 2016a; Aslani et al., 2016b; Athari, 2019). This evidence concerns the gene IL4 and asthma.