This mechanism of synthesis of collagen-1, Fli1-dependent fibrosis, emerges in several disorders associated with enhanced consumption of salt and includes age-dependent hypertension (Fedorova et al., 2023), preeclampsia (Nikitina et al., 2011), and CKD (Elkareh et al., 2007; Kolmakova et al., 2011). The gene discussed is FLI1; the disease is chronic kidney disease.