In 1988 using polyclonal antibody against MBG we demonstrated that MBG-like CTS exhibits increases in patients with CKD (Gonick et al., 1998), and several years later this observation was confirmed using a monoclonal antibody, while another CTS, endogenous ouabain, did not become elevated (Kolmakova et al., 2011). This evidence concerns the gene TTR and chronic kidney disease.