Pro-fibrotic effects initiated by MBG may also be TGFβ1/SMAD-dependent and underlie vascular fibrosis in salt-induced normotensive (Grigorova et al., 2018) and hypertensive rats (Zhang et al., 2019), but TGFβ sensitive mechanisms are not involved in preeclampsia (Nikitina et al., 2011) or chronic renal failure (Elkareh et al., 2007; Haller et al., 2012). The gene discussed is TGFB1; the disease is preeclampsia.