Numerous studies highlight associations between alterations in AQP4 expression or localization and various central nervous system diseases, such as ischemic stroke (Manley et al., 2000), epilepsy (Hubbard et al., 2016), neuropathic pain (Xian et al., 2021), and glioblastoma (Wang R. et al., 2023). Here, AQP4 is linked to central nervous system disorder.