TYMS and cancer: We did not obtain information about sensitivity to cisplatin and paclitaxel via the GDSC database, but low expression of FTO was less sensitive to 5-fluorouracil (an antimetabolite that inhibits thymidylate synthase) (Figure 7A), another commonly used chemotherapeutic drug, and sorafenib (Figure 7A), a multi-kinase inhibitor that is widely used in many types of cancer treatment.