METTL3 and colorectal carcinoma: In colorectal cancer (CRC), METTL3 upregulates plasminogen activator urokinase (PLAU) mRNA in a m6A-dependent manner and participates in the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway to promote tumor angiogenesis and metastasis (120).