Currently, an increasing number of studies have focused on the regulatory roles of m6A readers, such as insulin-like growth Factor 2 mRNA-binding protein 2 (IGF2BP2), IGF2BP3, YTH N6-methyladenosine RNA-binding protein 1 (YTHDF1), YTHDF2, and YTHDF3, in tumor occurrence, development, and angiogenesis. The gene discussed is YTHDF2; the disease is neoplasm.