BCL11B and leukemia: These data support the role of BCL11B overexpression as an oncogenic event in leukemia with T-cell markers.33,34 Our studies in human naïve T cells showed increased proliferation upon BCL11B overexpression and reduced proliferation upon its downregulation.35 The data suggest a potential role of BCL11B in tumor survival and encourage developing Bcl11b-inhibitory approaches as a potential tool to specifically target chemoresistant tumor cells.