ESR: Erythrocyte Sedimentation Rate; DAT: Direct Antiglobulin Test; ANA: Antinuclear Antibodies; Anti-dsDNA: Anti-double Stranded DNA Antibodies; SLE: Systemic Lupus Erythematosus; Anti-RNP: Anti-Ribonucleoprotein Antibodies; Anti-Sm: Anti-Smith Antibodies. The gene discussed is RNPC3; the disease is systemic lupus erythematosus.