It is recommended that patients with OSCC presenting advanced stages of the disease or those living in solitude undergo thorough evaluation to identify psychological distress and enable appropriate intervention strategies. Bernabe and colleagues [22] have documented that stress among patients with OSCC resulted in an upregulation of IL-6 production in reaction to stress, consequently contributing to the progression of stress-related OSCC. This evidence concerns the gene IL6 and Abnormal emotional state.