The SCN8A gene is associated with a severe developmental and epileptic encephalopathy (Ohba et al., 2014), cognitive impairment (Wagnon et al., 2017; Trudeau et al., 2006), and has a demonstrated relationship with reduced pathogenesis of AD in a mouse model study (Yuan et al., 2022). This evidence concerns the gene SCN8A and Cognitive impairment.