In addition to APOE, we replicated the same signals of ten known-AD loci (p ≤ 0.05): ABCA7, ANK3, CLU, FERMT2, GRN, PRDM7, RASGEF1C, SEC61G, SORL1, and TREM2 (Table 2; Figure 2). The gene discussed is GRN; the disease is Alzheimer disease.