The Mann–Whitney U test showed that the serum TNF-α (median 6.36, IQR 5.13–7.72) levels in MSA patients were significantly higher than those in HCs (median 4.27, IQR 0.99–5.76, p < 0.001, Table 1 and Figure 1A). The gene discussed is TNF; the disease is multiple system atrophy.