The Lasker Foundation has awarded the 2024 Lasker~DeBakey Clinical Medical Research Award to Joel Habener (Massachusetts General Hospital), Svetlana Mojsov (Rockefeller University), and Lotte Bjerre Knudsen (Novo Nordisk) for their pioneering work on glucagon-like peptide 1 (GLP-1) receptor agonists and their applications to obesity. This evidence concerns the gene GCG and obesity due to melanocortin 4 receptor deficiency.