TNFSF11 and Miyoshi myopathy: At the same time, urinary amino-terminal cross-linking telopeptide of type I collagen (NTX) and serum CTX generated by matrix metalloproteinases (ICTP) elevated in MM patients with osteolytic lesions and correlated with disease progression and overall survival.32 MM cells and their stromal cells upregulate the expression of RANKL, inducing myeloid precursor cells to differentiate into osteoclasts, enhancing the function and quantity of osteoclasts, and thereby exacerbating the occurrence and development of osteolytic lesions in patients.