Flow cytometric analysis confirmed that the mature lymphocytes were monoclonal cells expressing CLL markers (CD19+, CD5+, CD23+,CD25+, CD20+, CD200+, cLambda+, CD79bdim, CD10−, FCM7−,CD103−, CD38−, CD11c−, CD34−, and cKappa−, Figure 1b, R9, 34.15%), whereas monoclonal plasma cells were CD38+, CD138+, CD56+, cKappa+, CD117−, CD19−, CD7−, CD27−, CD28−, CD34−, HLA-DR−, CD22−, CD45−, and cLambda− (Figure 1b, R8, 3.02%). The gene discussed is CD38; the disease is B-cell chronic lymphocytic leukemia.