For example, Adduri et al. performed LC–MS/MS proteomic analysis on 163 plasma EV samples, including those from patients with IPF, CHP, and NSIP, and healthy controls, identifying EV proteins SFTPB, ALDOA, HMGB1, CALML5, and TLN1 as useful markers for distinguishing IPF from other ILDs [24]. The gene discussed is HMGB1; the disease is idiopathic pulmonary fibrosis.