APOE and Hypertension: We found a significant decrease in risk of all-cause dementia associated with college education or above among participants without hypertension regardless of the APOE4 gene with an RD of -5.5% (-8.3% to -2.7%) for those with APOE4 and − 2.4% (-4.3% to -0.4%) for those without APOE4. However, we found no significant decrease in risk among those with hypertension regardless of the APOE4 gene.