EZH2 and Intellectual disability: Olfactory anomalies have also been reported in nine of 16 patients with RSTS [10] and in one of 11 patients with Weaver syndrome, (WVS; OMIM #277590), caused by germline pathogenic variants in EZH2. WVS is a Mendelian disorder characterized by striking overgrowth intellectual disability and distinctive facies [17].