SPIC and hemophagocytic syndrome: The transcription factor spic was down-regulated by SPMs (Fig. S8b); spic (Spi-C Transcription Factor) is up-reregulated in Secondary hemophagocytic lymphohistiocytosis, a hyperinflammatory state in humans (Wang et al. 2019). Thus, these effector functions uncovered in the present experiments (Fig. S8) are in line with the SPM pro-resolving mechanisms (Serhan and Chiang 2023; Serhan 2014).