Consistent with enhanced interaction of Iba1-expressing cells with pericytes in AD (Fig. 4h), we found that the distance between P2Y12R-labeled microglial somata or CD206-labeled PVM somata and 1st–3rd branch order pericyte somata was reduced by 27% and 67%, respectively, in ADxNG2-dsRed mice compared to WT mice (Extended Data Fig. 6f). The gene discussed is P2RY12; the disease is Alzheimer disease.