Finally, combinatorial treatment with anti-CTLA-4 and survivin-derived peptide cancer vaccine, where the latter is characterized by high affinity for the murine analog of MHC-encoded class I molecule (H2-KK) [205], led to abrogation of tumors in mice bearing AgN2a and NXS2 NB tumors, and this was mediated by CD8 + T and NK cells [206]. The gene discussed is CTLA4; the disease is neuroblastoma.