Moreover, co-cultures of NB cells expressing HLA-Bw4 and NK cells lacking KIR3DL1, but expressing KIR3DS, a receptor for KI3DS1 on NB cells led to NK cell-mediated cytotoxicity, and this was linked to improved progression-free and overall survival (Fig. 2) [139]. The gene discussed is KIR3DL1; the disease is neuroblastoma.