Treatment with single agent, CTLA-4 antibodies in mice bearing GD2 expressing NB tumors (NXS2 or 9464D-GD2) did not result in reduced tumor volume, however, the combinatorial treatment with anti-CD40 monoclonal antibody and CpG-oligodeoxynucleotides greatly improved immune response by reinvigorating T cells and their response, and by reducing Treg population, but no differences in NK cells were found [203]. Here, CTLA4 is linked to neoplasm.