CD226 and neuroblastoma: Finally, expression of NK activating receptors, including DNAM-1, CD16, NKG2C, CD94, and NCR1, which positively correlate with genes associated with NK cytotoxicity, was lower in NB compared to expression in blood NK cells [75], and reduced expression of NKG2D and DNAM-1 was dependent on MYCN amplification [76].